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Obesity and mortality risk
Overweight and obese people have a higher probability of a more severe disease course and of pulmonary complications than individuals with normal weight. (1)One of the most important reasons of this fact may be the weakened parasympathetic functions and the cholinergic anti-inflammatory pathway marked by decreased heart rate variability (HRV). (2) Moreover, overweight people have…
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Dark chocolate may avert cytokine storm and improve the cholinergic anti-inflammatory pathway
Scientist found that daily consumption of 10g dark chocolate (minimally 70% cacao) significantly increased heart rate variability (HRV). (1) This effect of dark chocolate may indicate that it can decrease the cytokine storm induced by COVID-19 infection. The fatal consequences of COVID-19 are prognostized by the persistent elevation of the cytokine Il-6. (2) HRV is…
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Effect of air pollution for death rates and the possible mediating role of the cholinergic anti inflammatory pathway measured by heart rate variability (HRV)
According to a recent study air pollution is significantly increasing the death rates of coronavirus infection. Indeed, the effect of increased particulate matter in the air for the mortality rate of COVID-19 caused infection is 20 times greater than that of all cause mortality. (1) Particulate matter impairs HRV that is indicative of the damage…
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Proinsulin C-peptide as an inhibitor of virus invasion and inflammation in the brain and body
It is a recent discovery that coronavirus uses a protein CD147 also called EMMPRIN, to invade cells. (1) The amount of this protein is increased by mechanical ventilation according to experimental results. (2) For this reason mechanical ventilation may significantly enhance the virus infection of lung tissues. By activating PPARgamma, a nuclear receptor, it is…
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Gut barrier functions and lung injury
According to a retrospective study 86,7% of COVID-19 patients have gastrointestinal symptoms. (1) With the help of angiotensin converting enzyme-2 (ACE2) protein the virus has access to the human cells. It is abundantly present in the gastrointestinal tract and mostly in the epithelia of the small intestine and lung and in arterial and venous endothelial…
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Consequences of low oxygenation
It is among the most severe effects of the coronavirus infection that the high risk patients may have breathing problems. The oxygen supply of their body decreases. Independently of the causes of this problem, the oxygen deficiency, hypoxia may decrease heart rate variability (HRV). (1) HRV or the parasympathetic nervous system and the cholinergic anti-inflammatory…
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Hungarian researchers discovered the biological mechanism of COVID-19 related cytokine storm that proinsulin c peptide may prevent
SARS-CoV-2 can recruit the host protein phosphatase 2A (PP2A) and it manipulates by it the host’s antiviral responses.(1) With the help of PP2A the virus can overactivate cofilin, the actin severing protein, because manipulated and overactivated PP2A can dephosphorulate and so overactivate cofilin. (2) By overactivating cofilin the virus can overactivate the macrophages of the…
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Tragedies at respiration: the most severe cases are handled with an “ax”
To insert breathing tubes into patients, they get usually narcotized. Mainly with 2 active ingredients (Rocuronium, Vecuronium) that the US is starting to run out of. Why is it a tragedy?Well, because those who need it, they struggle with severe inflammatory reactions with extremely low vagus (parasympathetic, HRV) reserve. Based on the research of Prof.…
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Lung function and proinsulin c peptide
The biggest risk the COVID-19 carries in terms of mortality is the decrease in the lungs’ overall functionality. These functions may already be damaged due to other reasons as well, for example, smokers, people with diabetes mellitus, COPD and of course people with Asthma. Also, it is an interesting consequence of Type 1 diabetes, that…
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COVID-19 attacks antiviral lymphocytes: but there is a solution
(Send this to any immunologist you know, they will be happy to hear this news, maybe it is not too late.) The Corona Virus damages the antiviral CD8+ T cells, exactly those cells, which are responsible for defending us against the upper respiratory illnesses. The number of these cells and their functionality are shortened. In…