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Cofilin as the master regulator of the key covid inflammatory trigger NLRP3 and microglia activity as well as of the Shank3 protein effects: possible therapeutic implications for the brain and the body affected by Covid-19 infection
The NLRP3 inflammasome was identified as one of the most important inflammatory and apoptosis triggers in covid patients. i Its role in the inflammatory brain pathology caused by covid19 is also established. For example, the spike protein can increase the production of NRLP3 protein in microglia. ii The importance of this fact is highlighted by…